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To test the relevance of MEK/ERK activation in PIK3CA-driven VMs, we treated PIK3CA E542K vascular network with trametinib ( Fig. 6 and fig. S9C), a MEK1/2 kinase inhibitor that has proven to be ...

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ABSTRACT. Toll-like receptors (TLRs) and the receptors for interleukin (IL)-1, IL-18 and IL-33 are required for defence against microbial pathogens but, if hyper …

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